Hepatic microvascular dysfunction and endotoxemia in sepsis
نویسندگان
چکیده
منابع مشابه
Microvascular dysfunction in sepsis
Sepsis causes microvascular dysfunction. Increased heterogeneity of capillary blood flow results in local tissue hypoxia, which can cause local tissue inflammation, impaired oxygen extraction, and, ultimately, organ dysfunction. Microvascular dysfunction is clinically relevant because it is a marker for mortality: it improves rapidly in survivors of sepsis but fails to improve in nonsurvivors. ...
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Sepsis is a major life‐threatening health‐care problem. According to statistics, there are 20–30 million new cases of sepsis worldwide annually, which causes equivalent deaths from acute myocardial infarction and kills more people than breast cancer, stroke, and AIDS combined. About 41% of cases of sepsis progress to multiple organ dysfunction syndrome (MODS), resulting in mortality as high as ...
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Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction remain unclear, but there are considerable experimental data showing reduced microcirculatory flow, particularly of small vessels, and increased heterogeneity. With the development of newer imaging techniqu...
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Endotoxemia and sepsis often result in circulatory derangements which manifest as perfusion maldistributions. It has been widely accepted that the splanchnic circulation decreases in perfusion during advanced septic or endotoxemic states. Impaired perfusion of splanchnic organs may result not only in organ dysfunction but also exacerbations of polymicrobial bacteremia due to intestinal mucosal ...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2008
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2008.01.003